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Banji, David
- Method Development and Validation of Aliskiren Hemifumarate and Valsartan in bulk drug by RP-HPLC method
Abstract Views :463 |
PDF Views:2
Authors
Somsubhra Ghosh
1,
B. Anusha
1,
Santhoshi
1,
David Banji
1,
Y. Chaithanya Kumar
1,
P. Raghavendra
1,
Subhadip Roy
2
Affiliations
1 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, 508001, IN
2 Mylan Laboratories Ltd, Hyderabad, Andhra Pradesh, IN
1 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, 508001, IN
2 Mylan Laboratories Ltd, Hyderabad, Andhra Pradesh, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 1 (2013), Pagination: 19-23Abstract
A new simple, accurate, rapid and precise isocratic High Performance Liquid Chromatographic (HPLC) method was developed and validated for the determination of Aliskiren Hemifumarate (ALSK) and Valsartan (VAL) in bulk drug. The Method employs Waters HPLC system on C8 Column (4.6 x 250 mm, 5 μm) and flow rate of 1 ml/min with a load of 10μl. The Detection was carried out at 220 nm. mobile phase used as Acetonitrile and Phosphate buffer and Methanol was used as mobile phase in the composition of 45:40:15 , phosphate buffer (0.02Mm) adjusted the pH to 4 with Orthophosphoric acid within a short runtime of 8 min. The retention times of Aliskiren (ALSK) was 3.407 min, Valsartan (VAL) was 4.268 min. The method was validated according to the regulatory guidelines with respect to specificity, precision, accuracy, linearity and robustness etc.Keywords
Aliskiren Hemifumarate, Valsartan, HPLC, ValidationReferences
- http://www.drugbank.ca/drugs/DB00177
- Willard HH, Merritt LL, Dean JJA, Frank AS. Instrumental Method of Analysis. CBS Publishers and Distributors, New Delhi. 1986; 9th ed: pp. 580, 626.
- Sethi PD. High-performance liquid chromatography. CBS Publishers and Distributors, New Delhi. 2001 1,1-103,.
- Kemp WL. Organic Spectroscopy. Macmillan. 1991; 3rd ed: pp. 234-267. 5. http://www.drugbank.ca/drugs/DB01258
- Tatar S, Saglik S, Comparison of UV- and Second derivative- Spectrophotometric and LC methods for the determination of Valsartan in pharmaceutical formulation, Journal of Pharmaceutical and Biomedical Analysis, 30(2); 2002: 371-375.
- Macek J., Klima J. and Ptacek P.,“Rapid determination of Valsartan in human plasma by protein precipitation and high-performance liquid chromatography”, Journal of Chromatography, 832(1); 2007: 169-172.
- Pachauri SL, Paliwal SV, Srinivas KS, Singh YG, Jain VR. Development and validation of HPLC method for analysis of some antihypertensive agents in their pharmaceutical dosage forms. Journal of Pharmaceutical sciences and Research. 2 (8); 2010: 459-464.
- Sangoi MW, Sangoi MS, Oliveira PR, Secretti LT, and Rolim CB. Determination of aliskiren in tablet dosage forms by a validated stability indicating RP-LC method. Journal of Chromatographic Science, 49(2); 2011: 170-175.
- Swamy GK , Rao JS, Kumar JR, Kumar UA, Bikshapathi DR, Kumar DV. Analytical method development and validation of aliskiren in bulk and tablet dosage form by RP-HPLC method. Journal of Pharmacy Research, 4(3); 2011: 865-867.
- Satish KB, Rao JS, and Bhargava KV. A simple and sensitive method for the determination of aliskiren hemifumarate using HPLC-UV detection. Rasayan Journal Chemistry, 4(2); 2011: 285-288.
- Satana E, Altinay S, Göger N., Özkanb S. A., Sentürk Z.,Simultaneous determination of valsartan and hydrochlorothiazide in tablets by firstderivative ultraviolet spectrophotometry and LC, J. Pharm. Biomed. Anal, 25(5-6): 1009-1013.
- Shaboury SE, Hussein SA, Mohamed NA, Mohamed MS, Spectrofluorimetric method for determination of some angiotensin II receptor antagonists, Journal of Pharmaceutical Analysis, 2(1); 2012: 12-18.
- Yadav BR, Moinuddin MD, Battu RK, Samanthula GD, Development and Validation of a New RP-HPLC Method for the Estimation of Valsartan and Hydrochlorothiazide in Tablets, Journal of Analytical Chemistry, 2(8); 2012: 13-19.
- Patnaik A, Shetty M, Sahoo S, Nayak DK, Veliyath SK, A new rp-hplc method for the determination of valsartan in bulk and its pharmaceutical formulations with it’s stability indicative studies. International Journal of Pharmaceutical Sciences, 2(3); 2011: 43-53.
- Spectrophotometric (Vierodt's) Method for Simultaneous Estimation of Eperisone Hydrochloride and Diclofenac Sodium in Rapisone-D SR Capsules
Abstract Views :311 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, IN
2 School of Pharmacy, Taylors University, Subang Jaya, MY
1 Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, IN
2 School of Pharmacy, Taylors University, Subang Jaya, MY
Source
Asian Journal of Research in Chemistry, Vol 6, No 7 (2013), Pagination: 683-686Abstract
The present method describes simple, sensitive, rapid, accurate, precise and economical Spectrophotometric method for the simultaneous determination of Diclofenac Sodium and Eperisone Hydrochloride in bulk and capsule dosage form. The method is based on the Vierodts Method (simultaneous estimation)for analysis of both the drugs using distilled water as solvent. Diclofenac sodium (DIC) has absorbance maxima at 277 nm and Eperisone hydrochloride (EPE) has absorbance maxima at 255 nm in distilled water. The linearity was obtained in the concentration range of 2- 12 μg/mL and 3-18 μg/mL for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The concentrations of these drugs were determined by using vierodts equations. The mean % recovery (w/w%) was 99.3 and 100.3% for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The proposed method was found to be simple and sensitive for the routine quality control application of dosage form of Diclofenac Sodium and Eperisone Hydrochloride. The results of analysis have been validated statistically according to ICH guidelines.Keywords
Diclofenac Sodium, Eperisone Hydrochloride, Recovery, Vierodts Method, RAPISONE D SR capsules, Validation, ICHReferences
- Japanese Pharmacopoeia, 15th edition, Society of Japanese Pharmacopeia 2006: 618
- http://www.chemspider.com/eperisone.drugprofile
- Indian Pharmacopoeia, Vol. II, The Controller Publication, Govt. of India, New Delhi 2010: 1199.
- British Pharmacopoeia, Vol. I, The British Pharmacopoeia Commission, London 2010: 672.
- Skoog, A.D. and West M.D., Principles of instrumental analysis, Saunders golden, Japan, 3rd ed., 1985, 212-213.
- A.H.Beckett,J.B. Stenlake , Practical Pharmaceutical Chemistry, CBS Publishers and distributors, 1997; 4(2), 275-337.
- The International Conference on Harmonization, Q2 (R1), Validation of Analytical Procedure, Text and Methodology, 2005.
- Michael E, Schartz IS, Krull. Analytical method development and Validation. 2004, 25-46.
- The International Conference on Harmonization, Q2 (R1), Validation of Analytical Procedure, Text and Methodology, 2005.
- Ding L, Wang X, Yang Z, and Chen Y The use of HPLC/MS, GC/MS, NMR, UV and IR to Identify Degredation product of eperisone hydrochloride in the the tablets, J of pharm and Bio Anal, 2008, 46: 282-287.
- Nirav Uchadadiya, Falgun Mehta, Pinak Sanchaniya, “Development and validation of derivative spectrophotometric method for simultaneous estimation of Eperisone hydrochloride and Paracetamol in combined tablet dosage form”,Novus Int J of Chem, 2012, Vol. 1, No. 1, 33-40
- Priyanka Patel, Dhara Patel, Hardik Modi, Falguni Patel, Hardiksinh Baria, Sanjay Patel“development and validation of RP-HPLC methods for simultaneous estimation of eperisone hydrochloride and lornoxicam in bulk and their synthetic mixture” Inventi Rapid: Pharm Analysis and Quality Assurance , Vol. 2013 ,724
- MR Sengar, SV Gandhi , UP Patil, VS Rajmane “Simultaneous Determination of Diclofenac Sodium and Thiocolchicoside in Fixed Dose Combination by Spectrophotometry” Asian J of Pharm and Cli Res , Vol.3 Issue 2, April-June 2010 ,pg.no.86-9
- Chakraborty Mithun , Ray Chaudhury Dipanjan, Basu Arindam, Das Debabrata and Chakraborty Susanto, “Simultaneous Determination of Paracetamol, Chlorzoxazone and Diclofenac Sodium in Tablet Dosage form by HPLC”, Int J Of Pharm Innovations, Volume 2, Issue 2, pg.no.34-40
- D. S. Patel, A. D. Captain, P. P. Prajapati, H. G. Shah, “Development and Validation of HPTLC Method for Simultaneous Determination of Tolperisone Hydrochloride and Diclofenac Sodium in Combined Dosage Form” Int J of PharmTechand Res,Vol.5, No.1, pp 147-154
- J.Umang Patel, Patel Paresh.U,Patelo Sejal K “Spectrophotometric method for simultaneous estimation of eperisone hydrochloride and diclofenac sodium in synthetic mixture”, Int Res J of pharmacy ,2012,vol.3(9)pg.no.203-206